Antibacterial effect of Cannabidiol oil against Propionibacterium acnes, Staphylococcus aureus, Staphylococcus epidermidis and level of toxicity against Artemia salina

Acne is one of the most common skin pathologies; causes Propionibacterium acnes, an anaerobic and gram-positive microorganism that lives in hair follicles currently presents resistance to antibiotic-based treatments; this research topic has purpose evaluating antibiotic activity Cannabidiol oil against Staphylococcus aureus epidermidis level toxicity Artemia salina. For methodology, antibiograms were used by Kirby-Bauer method, where concentrations evaluated: 0,8 %; 0,6 0,4 0,3 % 0,1 Amoxicillin for positive control Dimethyl sulfoxide (DMSO) negative control; percentage inhibition acnes two bacteria calculated: epidermidis. Once was tested, a study carried out salina determine its LD50. The obtained from Ecuadorian company as agent be evaluated, it found at concentration 0,8%, presented 91,2 98,7 93,6 epidermidis, respectively, data do not present significant difference Amoxicillin; test, LD50 4,8 obtained; taking into account commercial presentation 1,6 (500 mg/30 mL), results relatively innocuous product. Thus concluding very promising due percentages low toxicity. Keywords: CBD, antibiograms, bioassay,